منابع مشابه
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.
The adult mammalian heart exhibits limited regenerative capacity after myocardial injury, a shortcoming that is responsible for the current lack of definitive treatments for heart failure. A search for approaches that might enhance adult heart regeneration has led to interest in the Hippo/Yap signaling pathway, a recently discovered signaling pathway that regulates cell proliferation and organ ...
متن کاملThe hippo pathway.
The Hippo pathway (Fig. 1), also known as the SalvadorWarts-Hippo pathway, regulates tissue growth in a wide variety of organisms (Harvey and Tapon 2007; Grusche et al. 2010; Oh and Irvine 2010; Pan 2010; Halder and Johnson 2011; Zhao et al. 2011). Many components of the pathway were identified as a result of mutations in the fruit fly Drosophila melanogaster that resulted in tissue overgrowth ...
متن کاملHippo on the move
Hippo and its mammalian homologs MST1 and MST2 are important tumor suppressors best known for their effects on cell proliferation and survival; however, accumulating evidence suggests that these kinases are involved in a wide range of cellular processes, including regulation of cell morphology, adhesion and migration. In the canonical pathway activated Hippo/ MST1/2 kinase phosphorylates and ac...
متن کاملCongenital Adrenal Hyperplasia and Schmid Metaphyseal Chondrodysplasia in a Child
Congenital adrenal hyperplasia (CAH) is a group of hereditary diseases, which are autosomal recessive. CAH occurs due to defect in one of the cortisol coding genes and often clinically presents itself with signs of androgen overproduction. In this article, we report a case of CAH and Schmid metaphyseal dysplasia. Our literature review indicated that this report is the first attempt on CYP11B1 a...
متن کاملActin up for Hippo.
The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal, Sansores-Garcia et al (2011) report that modulation of filamentous (F)-actin accumulation controls Hpo pathway activity. In a related study, GarciaFernandez et al (2011) confirm this finding, and also show that ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.119.314968